Evidence for involvement of the transcription factor Egr-1
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The peptide, derived from the C-terminal fragment of human growth hormone (amino acids 176-191), targets adipose tissue specifically without the broader metabolic effects associated with full growth hormone therapy
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The most common is based on the inhibition of its degradation in the cytosol, which is followed by its translocation to the nucleus, but it can also be activated by the effect of micromolar amounts of H 2 O 2