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As GSH has a net negative charge at physiological pH, the high concentration of mGSH implies the existence of specific transport systems that work against an electrochemical gradient (Griffith and Meister, 1985

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Neurosci Res 37:159, PMID: 10802340 Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

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