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While were talking about microdosing here (with the goal of avoiding significant weight loss), the truth is that we dont know what dose is small enough to avoid weight loss while still delivering health benefits

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Finally, beyond their role in controlling metabolic processes, GLP-1 receptor agonists also show promising potential benefits in treating cardiovascular and neurodegenerative diseases

When a person has very high blood sugar levels or other symptoms of type 2 diabetes, they need to use insulin

Endocrinology 149 , 56795687, (2008)

In addition to its glucose-lowering effects, metformin has been shown to reduce body weight and reduce the risk of cardiovascular events