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McGraw-Hill / Lange rxlist.com (Amaryl ) rxlist.com (Glucotrol ) rxlist.com (DiaBeta ) Keywords Glitinides Repaglinide Trade Name: Prandin Drug Class: oral hypoglycemic, insulin secretagogue, meglitinide, glinide Mechanism of Action: Similar to sulfonylureas - inhibits potassium efflux (blocks ATP-regulated K channels), causing depolarization & insulin release from pancreatic -cells (see Figure 1 in Beta Cell Pharmacology) has a weaker binding affinity and faster dissociation from the SUR1 binding site compared to sulfonylureas Stimulates a transient release of insulin from pancreatic beta cells that, when administered with a meal, is useful for controlling postprandial hyperglycemia associated with Type 2 diabetes (see Figure 2 in Beta Cell Pharmacology)

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