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In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999

However, in practice, we found the email turnaround to cover most of what a call would, since you are not waiting on hold for an answer you have already put in writing

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