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They can be safely used with all other glucose-lowering therapies except vildagliptin
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In addition, combining GLP-1R agonists with other peptide agonists or small-molecule therapeutics, including fibroblast growth factor 21 (FGF21), the farnesoid X receptor (FXR) agonist cilofexor with/without the acetyl coenzyme A carboxylase inhibitor firsocostat, a long-acting amylin agonist, cannabinoid receptor antagonists and sodium-glucose cotransporter 2 inhibitors (SGLT-2i), is currently being explored and may lead to additional improvements in NASH features vs GLP-1R agonists therapy alone [79,80,81,82,83]
Forest plot of the meta-analysis for the non-GLP-1 RA comparison using crude hazard ratios
Novo Nordisks semaglutide franchises (Ozempic for diabetes
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