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However, A1c, which reflects your average blood sugar over roughly three months, will not show meaningful changes on lab work until you have been on the medication for at least eight to twelve weeks
This distinction has shown to provide substantial weight reduction and improved glycemic control in adults with obesity and type 2 diabetes
Injectable GLP-1s may be more suitable for: Patients aiming for the maximum possible reduction in body weight, those with co-existing conditions like heart disease or chronic kidney disease (due to specific FDA approvals for Ozempic), or those who prefer a simple weekly medication schedule
Although not approved specifically for PCOS, GLP-1 RA use in women with PCOS has been associated with improved blood glucose control and weight loss, as well as improvements in menstrual regularity and a decrease in ovarian cysts ( 4 , 6 8 )
Subsequent meta-analyses of cardiovascular outcomes trials with GLP-1RAs have clearly excluded a causal role for GLP-1RAs in acute pancreatitis (63, 69, 70), while therapy with inhibitors of dipeptidyl peptidase-4 may lead to a minor elevation of this risk (69)
doi: 10.1136/gut.28.2.166
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