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Glucagon is liberated from pancreatic cells by PC2, wherea GLP-1 and GLP-2 are liberated from the intestinal L cells by PC1/3

61 The investigators calculated the proportional report ratio for GLP-1 RA and thyroid cancer and found the thresholds for reporting a new safety signal were fulfilled for exenatide, liraglutide, and dulaglutide as thyroid cancer was reported relatively more frequently with these drugs compared with all other drugs in the database

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A phase II study is currently investigating the neuroprotective effects of injectable semaglutide in 270 Parkinsons patients in a double-blinded, placebo-controlled design (NCT03659682)