The use of antioxidants or immunosuppressant drugs to reduce ROS production is already widely used in clinical practice (Bergqvist and Ezzedine, 2020)
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Both thyroidectomy and radioactive iodine therapy frequently induce iatrogenic hypothyroidism, leading to persistent cognitive slowing, low mood, and fatigue, while the psychological burden of cancer increases the risk of anxiety and depressive symptoms (12, 13)
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An ideal PD model would exhibit a high level of construct validity, indicating a similar disease pathogenesis (e.g., involving oxidative stress, inflammation, complex I inhibition, or proteasome inhibition), face validity, reflecting comparable symptoms (e.g., dyskinesia, rigidity), biochemistry (e.g., decreased striatal DA and altered downstream neurochemistry), and pathology (nigrostriatal tract degeneration and Lewy body formation) to the human condition, as well as predictive validity, signifying the capacity to accurately identify clinically effective treatments (Betarbet et al
