Another example is systemic lupus erythematosus (SLE), a systemic autoimmune disease characterized by the production of autoantibodies against nuclear antigens
Local reaction characteristics: Confined to the injection site and immediately surrounding area Symptoms include redness, swelling, itching, pain, and warmth at the injection site only No systemic symptoms (no fever, no hives elsewhere, no breathing difficulty) Resolves within 3 to 7 days Does not typically worsen after the first 24 to 48 hours Systemic allergic reaction characteristics: Symptoms extend beyond the injection site Hives, rash, or flushing on areas distant from the injection site Respiratory symptoms (coughing, wheezing, throat tightness) Cardiovascular symptoms (rapid pulse, low blood pressure, dizziness) Gastrointestinal symptoms (nausea, vomiting, cramping) beyond typical GI side effects Local reactions almost never require discontinuation of tirzepatide
PMC 6641943
Cagrilintide, with six amino acid substitutions in human amylin and a dual carboxylic fatty acid chain similar to semaglutide attached to the first amino acid, lysine, exhibits an extended half-life, allowing for a once-weekly subcutaneous administration regimen [97,98]
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