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The earliest realistic timeline for UK availability is 2028 or later, following anticipated phase 3 data in 20252026, a potential MHRA submission in 20262027, and subsequent NICE appraisal

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Polyphenolic compounds, including hazel leaf polyphenols, exert dual inhibitory effects on XOR activity and OAT1/hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene expression, with molecular docking studies predicting PI3KAKT pathway involvement (Wang R