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Although many of the contradictory results and conclusions reported over the years can be attributed to lack of understanding of established mechanisms, methodological problems, and misinterpretation of data, it is increasingly recognized that some of the reported differences in signaling mechanisms and even a switch in the mode of cell death can be caused by variations in the experimental conditions

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conversely, lowering blood glucose concentrations lowers oxidative stress (7,8)

614 Its efficacy in painful DN is currently under investigation

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J Clin Endocrinol Metab (2001) 86(8):380914.10.1210/jcem.86.8.7787 42 PeverelliEBusnelliMVitaliEGiardinoEGalsCLaniaAGet alSpecific roles of Gi protein family members revealed by dissecting somatostatin receptor 5 (SST5) coupling in human pituitary cells