GLP-1 receptor agonists including semaglutide, liraglutide, and the GLP-1 component of tirzepatideexert their effects by binding to GLP-1 receptors in the gastrointestinal tract and brain
Ring et al., 2010, Ring et al., 2014
found that GLP-1 receptor agonist use, compared with initiation of sodium-glucose cotransporter 2 (SGLT2) inhibitors, was associated with a lower risk of composite MALOs (aHR: 0.84, 95%CI: 0.74-0.94), including specifically lower occurrence of liver decompensation (aHR: 0.83) and all-cause mortality (aHR: 0.84) [56]
However, the changes in markers of autophagy and mitophagy in this process are unclear
Tobb shares three GLP-1 alternatives that may help support blood sugar control and weight loss
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