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Kabir MS, Dutta PK, Islam MN, Hasan MJ, Mondol G

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In HG-induced human renal proximal tubule cells (HK-2) and high-fat diet-fed combined streptozotocin (HFD/STZ)-induced diabetic mouse models, ubiquitin-like with PHD and ring finger domains 1 (UHRF1) overexpression through inhibition of thioredoxin-interacting protein (TXNIP) expression promotes PINK1 mediated mitophagy by inhibiting TXNIP expression, thereby inhibiting ferroptosis [117]