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Guidelines NICE (UK), NHS MSK pathways, and British Society for Surgery of the Hand These typically recommend: Conservative management first, including: Activity modification NSAIDs Splinting (usually 26 weeks) RCT evidence: 2023 JAMA Network Open Systematic Review & Network Metaanalysis (30 RCTs, n=1,663) Findings: Corticosteroid injection + thumb spica splint = best outcomes for pain and function

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1 February 2024

Growth hormone secretagogues, for example, prompt the pituitary gland to release more of its own growth hormone

Correlation of Clinical, Functional and Morphologic Features in FortySeven Patients, American Journal of Medicine 33 (1962): 349357

While this mechanism remains speculative, the underlying physiology of cryotherapy-induced blood flow changes supports the concept