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148 The increased LDL, lipocalin-2, and hepatokine fetuin, as well as reduced adiponectin, may promote fat accumulation in the pancreas, which might be enhanced by inflammation and oxidative stress through the serine/threonine protein kinase 25 pathway

By accumulating in tumor endothelium and immunosuppressive TAMs, they restore antigen presentation and unleash T cell mediated tumor clearance

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Moreover, a recent study reported that activation of peroxisome proliferator-activated receptor-/ could protect rat pancreatic cells from PA-induced apoptosis through upregulation of GLP-1R expression 31

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