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The homeostasis model assessment quantified insulin resistance (HOMA-IR), which was calculated as follows: HOMA-IR = [fasting blood glucose (mmol/L) fasting insulin (mIU/L)]/22.5

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TIZI-035/001WO 322161-2568 In another aspect, provided herein is a method for the treatment of chronic inflammation in a subject, the method comprising administering to the subject (1) foralumab and (2) a GLP-1 agonist or an SGLT-2 inhibitor

There is now evidence that they confer benefit beyond weight loss, including a recent large clinical trial demonstrating protection against cardiovascular disease