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GLP-1RAs suppress NLRP3 inflammasome activation via attenuating the expression of NLRP3, apoptotic speck containing protein (ASC), and cleaves caspase 1 (p10) [111]

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Tirzepatide works differently by targeting two hormones instead of one, and clinical studies show it can produce greater weight loss results than semaglutide for many patients

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One potential explanation for this finding is the high levels of stress-induced alterations in gene expression (e.g., increased expression of mitochondrial transcripts) within this subcluster