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Moreover, CICR requires continual activation of VDCCs by Ca 2+ within intracellular microdomains, but not by robust Ca 2+ influx from extracellular spaces [8,15,17,24]

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Challenges and recent advances in diagnosing Wilson disease

Here Glutathione takes over this process, recycling and reactivating them, in order to make them functional for their neutralizing "scavenger" activity

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