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23,24 In a network meta-analysis, Karakasis et al found that 15 mg tirzepatide and 2.4 mg semaglutide were the most effective agents for reducing body weight and fat mass

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Growth hormone-releasing factor (GHRF), also known as growth hormone-releasing hormone (GHRH), is a hypothalamic peptide that acts on the pituitary somatotroph cells to stimulate the synthesis and pulsatile release of endogenous growth hormone (GH), which is both anabolic and lipolytic