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At 6 months, weight reduction averaged 5%, with semaglutide, liraglutide, and exenatide showing comparable effects, while lean mass remained largely preserved

Ongoing phase 3 trials are expected to provide more comprehensive data on retatrutides potential as a therapeutic option for obesity and its related complications

For more guidance on what to eat while managing side effects, see our guides on foods to eat on semaglutide and what to eat on tirzepatide

For women, hormonal interactions add another layer of complexity

Given that the half-life of SGLT2 inhibitors varies from 11 to 13 hours, it seems reasonable to withhold these medications for three days (or five half-lives) before elective surgery

Compared with participants who received a placebo, those treated with semaglutide showed slower aging patterns across multiple epigenetic clocks associated with inflammation and the health of several major organ systems, including the heart, brain, kidneys, liver, blood, and metabolic system