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The phase 2 glycemic data, in which retatrutide lowered rather than raised HbA1c in participants with diabetes, are the practical evidence that the balance held in that trial

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For those who are post-medication, starting a structured program sooner improves the recovery trajectory

Ocular complications have also been reported in some cases

The STEP 1 trial found that people taking 2.4 mg of semaglutide weekly lost an average of 15% of their body weight over about 16 months