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The pharmacodynamic differences with liraglutide were shown in the phase II comparison, in which lixisenatide OD had a significantly greater PPG-lowering effect than liraglutide OD after a standardized breakfast test in patients with type 2 diabetes [11]

Treatment Protocol Begin with conservative dosing (200-300 mcg daily or 500 mcg twice weekly) and titrate based on response

A personalized peptide-infused drug

Previous human trials have shown that subcutaneous administration of oxyntomodulin three times daily for 4 weeks resulted in 1.8 kg greater weight loss than controls [44] as a result of increased activity-related energy expenditure (143 kcal/day) and decreased energy intake (128 kcal) [45]

however, this group reported that alpha-cells with this immature transcriptional profile also exhibited an impaired electrophysiological phenotype and dysregulated exocytosis (73)