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Recent trial data demonstrate that these benefits extend to individuals without diabetes, underscoring their role as cardiometabolic therapies rather than purely glucose-lowering medications [50, 51]

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The full length N-terminal extended forms of GLP-1 (137 and 136) are biologically inert

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The goal is to ensure intravenous support is offered only when appropriate and likely to provide meaningful benefit

Patients with these risk factors should discuss screening and supplementation strategies with their GP, particularly if experiencing symptoms such as fatigue, paraesthesia, glossitis, or cognitive changes suggestive of deficiency