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, Pourov, J

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Although PDT was the first therapy to show significant decrease in high grade dysplasia and cancer in patients with BE, its use has been limited, primarily because of its costs and its complications: Photosensitivity (can persist from 30-90 days after injection with the photosynthesizing drug) Strictures (tend to occur in about one third of patients treated, and normally happen 3 to 4 weeks after therapy) Subsquamous Barretts mucosa (buried Barretts can be found when the Barretts mucosa is not eliminated by therapy and is overgrown by surrounding squamous mucosa) Chest pain Nausea Vomiting Cryotherapy By freezing tissues to extreme cold temperatures, cryotherapy attempts to remove abnormal cells and allow for the re-growth of new, healthy cells in their place

Nature 435 , 673676 (2005)

Zhang H, Chen S