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No specific diet is required, but moderate calorie reduction and adequate protein intake meaningfully improve outcomes

Phase 2 (2022-2023) Phase 2 trial results generated significant attention in the medical community: Obesity trial results were published in the New England Journal of Medicine in 2023, showing weight loss of up to 24.2% at the highest dose over 48 weeks

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Regular resistance training preserves lean mass and supports insulin sensitivity through mechanical pathways that complement GLP-1 activation

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