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10.4168/aair.2017.9.1.79 22 YuliwulandariR.KashiwaseK.NakajimaH.UddinJ.SusmiarsihT

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Morning dosing is recommended for bioavailability and circadian alignment, not because the compound causes wakefulness or disrupts sleep when taken at other times

In mammals, this multitasking indolamine is synthesized in the pineal gland in a circadian manner in response to the photoperiodic information received via the retinohypothalamic pathway 4,5

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