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Hence, the macrocyclic disulphide 15 encompassing an 11-membered macrocycle was more potent as an IRAP inhibitor than the native Ang IV and exhibited a Ki value of 26 nM (Figure 5)

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When administered intranasally to adult mice at 0.22 mg/kg per day for seven days, LM22A-4 activates Trk, AKT, and ERK signaling in vivo

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Germain et al., 2018, 2022

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Addressing these deficiencies often improves hair health without peptide therapy

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