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Precautions Not recommended for patients with Type 1 Diabetes

Functional (primary) constipation has multiple possible causes

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High pH fractionation- TMT labeled, combined, and dried samples were resuspended in 300 L of Buffer A (5% v/v MeCN, 95% v/v H 2 O, 0.1% v/v formic acid) and fractionated by centrifugation using a peptide desalting column (Pierce, #89852)

All studies done thus far show up to 4 weeks continuous administration with a minimum of 2 weeks off

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