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Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]
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Hunter Guevara LR, Beam WBB, Pasternak JJ (2024) To the Brain and Beyond: Neurological Implications of Glucagon-Like Peptide-1 Receptor Agonists
GLP-1 can cause a reduction in weight and appetite, with gastrointestinal side effects associated with greater weight loss [95]
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