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A 2023 review in the Journal of Obesity found no evidence that B12 supplementation independently accelerates weight loss in patients taking semaglutide

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The most commonly reported is mild injection site redness or warmth, which typically resolves within minutes

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

Its important to note that for individuals with adequate vitamin B12 levels, there is limited scientific evidence that B12 injections alone will enhance skin hydration or appearance