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All patients were required to have continuous enrollment of at least 12 months before cohort entry and meet eligibility criteria for one of the five cohort studies defined below (study design diagrams depicted in Supplementary Figs

Sources: Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Sanchez M, Seoane L, Wadden TA