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The SELECT cardiovascular outcomes trial (N=17,604), published in NEJM 2023 (DOI: 10.1056/NEJMoa2307563), demonstrated a 20% reduction in major adverse cardiovascular events (MACE) -- the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke -- in overweight or obese adults without diabetes

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Amino acid deprivation induces TXNIP expression by NRF2 downregulation

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When the body experiences chronic stress, the adrenal glands work overtime to produce cortisol, the primary stress hormone