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To understand the comparison, you have to look at their structural origins and their incretin receptor affinities

2.3.2 Gut microbiota and its metabolites modulate GLP-1 secretion Emerging evidence highlights a bidirectional regulatory interplay between the gut microbiota and GLP-1, whereby microbial composition and metabolites exert profound influences on GLP-1 synthesis, secretion, and signaling

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Medically reviewed by Veronica Hackethal | MD, MSc , Harvard University | University of Oxford | Columbia Vagelos College of Physicians and Surgeons on March 26th, 2026