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While the petitions grievances are specific to peptides, they reflect long-running criticisms of the FDA, which has often come under fire from patient advocacy groups who want better access to experimental treatments that might ease the progression of deadly diseases

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In obesity, abnormal adipose metabolism transports large amounts of free fatty acids to the liver, increasing hepatic fat synthesis, decreasing fat breakdown, and ultimately causing hepatic steatosis

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Serious hypersensitivity reactions have also been reported during postmarketing use with other GLP-1 receptor agonists