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According to WHO and other researchers, if nothing is done to curb the problem, the global cost of overweight and obesity could potentially reach US$3 trillion per year by 2030 and more than US$18 trillion by 2060 (WHO 2024

(Lausanne) 13 , 1033479 (2022)

The FDA initially approved semaglutide under the brand name Ozempic in 2017 for managing type 2 diabetes, though it is sometimes prescribed off-label for weight loss

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Development, preclinical, and early clinical data on the GIP/GLP-1 receptor agonist tirzepatide Among the GIP/GLP-1 receptor agonists, tirzepatide (LY3298176) is the compound that is the most advanced in development and the first substance in this class that has received approval for the therapy of T2D by the FDA in May 2022 (manufacturer Eli Lilly Comp., trade name Mounjaro ) (5355)