Joshua Silva, MD Nov 7, 2025 13 min read Updated: Apr 17 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As GLP-1 and GLP-1/GIP medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) continue to transform medical weight management, one question comes up repeatedly: Do these medications cause muscle lossor even muscle wasting
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They found that individuals with major depressive disorders (MDD) had lower levels of GLP-1 hormone in their blood compared to healthy controls, and that increasingly lower GLP-1 levels were associated with worsening depression and anxiety scores
Adan, GLP-1 receptor agonist GLP1-S reduces appetite while increasing dopamine reward signaling, Neuroscience Applied, Volume 3, 2024, 103925, ISSN 2772-4085
The drugs, which have historically been prescribed to diabetic patients, also help patients lose weight and have grown in popularity among doctors and patients
GLP-1 drugs are primarily recommended for: Adults with type 2 diabetes who arent seeing results from oral medications and need better blood sugar control People with obesity or with a BMI over 30 (with or without diabetes) seeking medical weight management Doctors may also consider GLP-1 RAs for patients with cardiovascular risk factors, as some of these drugs have shown heart-protective benefits
