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metabolic changes during treatment reflect normal adaptation to weight loss rather than drug-induced harm

When GSSG accumulates excessively due to dysfunctional SLC33A1 activity, this inhibits enzymes required for proper disulfide bond formation and quality control, resulting in protein misfolding and aggregation within the ER

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This novel medication will likely be used in instances similar to GLP-1 RAs especially in patients with diabetes with high A1Cs and patients with diabetes with a compelling need to lose weight

doi: 10.1124/dmd.117.076034 16 ChenY

A comprehensive data review confirmed GLP-1s present no increased risk of suicide , leading the FDA to request the withdrawal of the warnings