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Early studies showed that people on GLP-1s lost quite a bit of lean mass, which some took to mean the loss of muscle

GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions

Sustainable weight control solutions emphasize balanced nutrition, constant activity, and mental wellness, unlike short-term diets that often lead to yo-yo dieting

The cost of semaglutide, particularly when used for weight loss (under the brand name Wegovy), tends to be on the higher end compared to other weight loss medications

The glucagon component appears to drive this effect by promoting hepatic fat oxidation

Exclusion criteria included non-human studies, articles not in English, and review articles (e.g., systematic reviews, meta-analyses)