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This Perspectives article describes the biophysiology of ACTH, with an emphasis on its melanocortin actions, particularly in renal parenchymal cells, which could potentially explain the therapeutic effects of ACTH in nephrotic glomerulopathies

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A recent research study found that estrogens reduce calcium response to drugs that cause bronchoconstriction via an estrogen receptor (ER)

We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety

A healthy individual should have a high amount of GSH and a very low amount of GSSG