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The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells

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Case reports and observational data have documented darkening of existing moles, appearance of new nevi, and changes in mole shape or size during Melanotan II use

28 However, there are no GLP-1 receptors in the eye so it is most likely that any worsening of retinopathy is related to the rapid fall in glucose levels with these agents

Deletion of hepatocyte-specific DPP4 in these aged mice did not affect glucose tolerance as only whole-body deletion of DPP4 increased systemic active GLP-1 and led to reduced blood glucose excursion during oral glucose tolerance test (Supplemental Figure 3, A and B), consistent with previous work (22, 23)

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