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Effect of titanium dioxide nanoparticles on male and female reproductive systems

It has been proposed that damage caused by ROS and RNS including HNE causes impaired glucose metabolism and electrochemical gradients across membranes which in turn affects calcium homeostasis (Butterfield and Halliwell 2019)

62 Moreover, CPTIC is an essential downstream mediator of the AMPK pathway as well as a target gene of p53 in a p53/AMPK-dependent manner

Biochim Biophys Acta Mol Cell Biol Lipids (2020) 1865:158662

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In a dose-ranging study in ESRD patients undergoing hemodialysis, patients received 10, 20, or 40 mg/kg levocarnitine 3 times per week following dialysis (N~30 for each dose group)