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IL-6, a key proinflammatory cytokine, is upregulated in multiple OA-related joint compartments, including synovial tissue, cartilage, and synovial fluid, where it promotes matrix degradation and inflammation (39)

The process involves a starting phase with the lowest clinically effective dose, an adjustment phase with monthly progress check-ins, and eventually a maintenance phase designed to preserve achieved weight loss outcomes

If also taking insulin or sulfonylureas, dose adjustments may be needed to prevent hypoglycemia

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Brain aging shows up on three different measures Before ranking what changes brain aging, it helps to lay out the three main ways it is measured, since these are the readouts usually assessed when determining efficacy

NCT04093752) and for chronic weight management (SURMOUNT-CN