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Liraglutide often costs less than semaglutide and might result in fewer side effects

In patients with HFpEF and obesity, both semaglutide (STEP-HFpEF) and tirzepatide (SUMMIT) significantly reduced cardiovascular death and worsening heart failure events, with concomitant improvements in quality of life and functional capacity [3,47]

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Existing literature suggests that the addition of the glucagon receptor creates a synergistic effect