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We highlight this as an important area for future investigation

28 At the cellular level, NTBI, which is accepted as the unstable iron pool, is composed of ferrous iron bound by low-affinity iron chelators

It mainly affects women of reproductive age

Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)

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They are tools that work best when the underlying body is optimized: adequate muscle mass, solid nutrition, good sleep, and hydration