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Its significance is rooted in its endogenous nature

Related Disorders of Hexose Monophosphate Shunt and Glutathione Metabolism In addition to G6PD, other enzymes of the HMP shunt pathway (6-phosphogluconate dehydrogenase [6PGD]), the closely linked reactions of glutathione metabolism (GSSG-R, GSH-Px), and the glutathione synthetic pathway are important in protecting RBC against oxidant injury

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Glutathione, a powerful antioxidant composed of three amino acidsglycine, glutamic acid, and cysteineplays a vital role in neutralizing free radicals, detoxifying harmful chemicals, and supporting numerous chemical reactions in the body