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As with any supplement, periodic breaks (three months on, one month off) are a reasonable precautionary approach, particularly for individuals with no confirmed deficiency or elevated oxidative stress markers
The shortest time needed for the appearance of melanosis coli in a patient who takes cascara preparation is four months and the longest is thirteen months (on average nine months)
Pigmented extramammary Pagets disease of the axilla mimicking melanoma: Case report and review of the literature
doi:10.1046/j.1524-475x.2003.11105.x
Duloxetine treatment and glycemic controls in patients with diagnoses other than diabetic peripheral neuropathic pain: a meta-analysis
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