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Of note, hemolysis is a fundamental feature of SCD and resulting excess hemin exposure 32 while hypoxia has been shown to induce the expression of fetal hemoglobin 33,34 , and promote the transition from expansion to differentiation during stress erythropoiesis 35

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Acknowledgements The authors express their sincere gratitude to the management of Noida Institute of Engineering and Technology, Pharmacy Institute, for their continuous support, motivation, enthusiasm, and immense knowledge

Neuropharmacology 110 (Pt B), 563573

Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing