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The circadian clock regulates rhythmic activation of the Nrf2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

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It was originally studied in equine medicine for tendon and muscle recovery, and interest in human therapeutic applications grew as the preclinical data on tissue regeneration, anti-inflammatory effects, and angiogenesis accumulated

Circulation 136 , 11141122 (2017)