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Consequently, GPX3 promotes tumor invasiveness and chemoresistance

Due to deficiencies in mtDNA repair mechanisms, lack of histone protection, and the proximity of mtDNA to the IMM where ROS are generated, mtDNA is highly susceptible to oxidative damage [81]

5.3 Microbial-ferroptosis interaction as a therapeutic target of IBD Collectively, accumulating studies suggest that the microbiotametaboliteferroptosis axis contributes to IBD pathogenesis ( Table 1 ) (132)

ORM-6151 (BMS-986497) is currently being clinically evaluated in patients with AML and MDS, while the pre-clinical ORM-1153 may expand Orums presence into additional hematologic malignancies

Cortisol dysregulation in obesity-related metabolic disorders